Service
MILS INTERNATIONALS urine metabolomics test service
Our method using GC / MS technology can detect more than 260 metabolites and can analysis glucose metabolism with high accuracy from very little quantity of urine. Therefore, more than 160 kinds Inborn Error Metabolism(IEM) in children and Diabetes Mellitus(DM), Gestational Diabetes Mellitus(GDM), Impaired Glucose Tolerance(IGT) in adult can be found in the early stages.
Compared with the blood spot new born screen test, our urine test is non-invasive, can screen more IEMs and not only without pain but also without fear of infections.
Furthermore, our mailable test device, having a patent and called “urine-filter paper set”, can save you or your children from going to the hospital for laboratory diagnostic test. Our test is also a "self-health care" suitable for busy people cautious about their health.
Make a request for our home test service by e-mail, and tell us your name, address, phone number and choice of tests for DM or IEM.
We will send you the test set on your request.
Test charge
33,000 yen (Tax included)
MILS on-line IEM screening system
Q & A for MILS IEM screening test
Q1. What are the IEMs to be screened?
A1. More than 160 IEMs can be checked. The detail please see “MILS Lab Screening Target Disease”.
Q2. Where the filter paper set can be purchased?
A2.The filter paper set will be sent to you after confirming your registration for our test by e-mail or Tel or Fax.
Q3. How to be as MILS network laboratory?
A3. If your hospital hope to setup IEM diagnosis laboratory in your hospital using MILS method you can contact us.
Q4. Where can be contacted when there are any questions?
A4. Please contact with bellowing:
Dr. Chunhua Zhang
e-mail: mils@mils-int.jp
Tel: +81-45-548-5580
Fax: +81-45-548-5590
MILS IEM Screen Technique Publication
- Matsumoto I. Kuhara T. 1996. A new chemical diagnostic mehod for inborn errors of metabolism by mass spectrometry. Mass Spectrom Rev 15:43-57
- Zhang C, Xu K, Dave UP, Wang Y, Matsumoto I Inborn errors of metabolism discovered in Asian department of pediatrics and mental retardation research center. J Chromatogr B Biomed Sci Appl. 2000 Sep 1;746(1):41-9.
- Matsumoto I. and Zhang C. Application of mass spectrometry during medical clinical J Medical Technology 44:1 27-35, 2000
- Xu K, Wang L, Cai H, Zhang T, Zhang C, Matsumoto I Screening for inborn errors of metabolism using gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001 Jul 5;758(1):75-80.
- Song Y., Zhang T., Zhang C. and Wang Z. Selective Screening of Inborn Errors of Metabolism by UP-GC-MS: Pilot Study of 327 Patients at High Risk. J. Appl. Clin. Pediatr. 20:2 142-144, 2005
- Zhang C. Prevention, Diagnosis and Therapy of Inborn Errors of Metabolism. Submitted to Chinese J Contemporary Pediatrics (CJCP). 2005
- Zhang C. Zhang M. Clinical test and diagnosis of inborn errors of metabolism. Clinical test and diagnosis book (Jianyan yu linchuang Zhenduan Congshu), Pediatrics part, Peoples military medical press 45:130. 2006.
- Zhang C. Application of Mass Spectrometry Technique for Children Metabolic Liver Disease Diagnosis J Clini Hepatol. July 2011 Vol 27. No.7 p709-717
- Meijer, J.; Nakajima, Y.; Zhang, C.; Meinsma, R.; Ito, T.; van Kuilenburg, A.B. Identification of a novel synonymous mutation in the human beta-Ureidopropionase Gene UPB1 affecting pre-mRNA splicing. Nucleosides Nucleotides Nucleic Acids 2013, 32, 639-645.
- Shu J, Zang Y, Jiang S, Zhang C. Meng Y, Wang H, Song L Mutation analysis of a family with 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency Chin J Pediatr, October 2013 Vol 51 No.10 :783-786
- Zhang C. Speedy identification of inherited metabolic disease in emergency and critical care center Chin Pediatr Emerg Med, Jun 2014, Vol.21, No.6: 341-345
- Zhang C Application of mass spectrometry for the clinical diagnosis of inborn errors metabolism, laboratory medicine May 2015 Vol30:5p410-415
- Shu Jianbo, Lin Shuxiang, Meng Yingtao, Zhang Chunhua, Xu Haiquan, Zhang Yuqin, Huang Jingfu Analysis of UPB1 gene mutation in a family affected with β-ureidopropionase deficiency Chin J Med Genet, October 2015 Vol 1 No.5 :647-650
- Yoko Nakajima, Judith Meijer, Chunhua Zhang, Xu Wang, Tomomi Kondo, Tetsuya Ito, Doreen Dobritzsch and André B. P. Van Kuilenburg Altered Pre-mRNA Splicing Caused by a Novel Intronic Mutation c.1443+5G>A in the Dihydropyrimidinase (DPYS) Gene Int. J. Mol. Sci.2016,17,86;doi:10.3390/ijms17010086
- Zhang C Metabolic disease and electrolyte disturbance Chin Pediatr Emerg Med, Oct 2016, Vol.23, No.10: 668-672
- Zhang C Expert consensus on inborn errors of metabolism screening PRECISION MEDICINE IN CHINA A Sponsored Supplement to Science p62-66.2016
- Yulian Fang, Chunquan Cai, Chao Wang, Bei Sun, Xinjie Zhang, Wenxuan Fan, Wenchao Hu, Yingtao Meng, Shuxiang Lin, Chunhua Zhang, Yuqin Zhang, Jianbo Shu, Clinical and genetic analysis of 7 Chinese patients with b-ureidopropionase deficiency Fang et al. Medicine (2019) 98:1
- Junling Wang, Zhimei Liu, Manting Xu, Xiaodi Han, Changhong Ren, Xinying Yang, Chunhua Zhang and Fang Fang Clinical, Metabolic, and Genetic Analysis and Follow-Up of Eight Patients With HIBCH Mutations Presenting With Leigh/Leigh-Like Syndrome Front. Pharmacol., 08 March 2021 Sec. Pharmacogenetics and Pharmacogenomics Volume 12 - 2021 https://doi.org/10.3389/fphar.2021.605803
- Ping Wang, Jianbo Shu, Chunyu Gu, Xiaoli Yu, Jie Zheng, Chunhua Zhang and Chunquan Cai Combined Malonic and Methylmalonic Aciduria Due to ACSF3 Variants Results in Benign Clinical Course in Three Chinese Patients Front. Pediatr., 25 November 2021 Sec. Genetics of Common and Rare Diseases Volume 9 - 2021 | https://doi.org/10.3389/fped.2021.751895
- Dandan Yan1, Shaopei Chen, Fengying Cai, Jianbo Shu1, Xiufang Zhi 1, Jie Zheng1, Chunhua Zhang, Dong Li and Chunquan Cai Complicated Hereditary Spastic Paraplegia Caused by SERAC1 Variants in a Chinese Family Front. Pediatr., 11 February 2022 Sec. Genetics of Common and Rare Diseases Volume 9 - 2021 | https://doi.org/10.3389/fped.2021.816265
- Jianbo Shu1, Xiufang Zhi 1, Jing Chen, Meifang Lei, Jie Zheng, Wenchao Sheng, Chunhua Zhang, Dong Li and Chunquan Cai Case Report: A Case of β-Ureidopropionase Deficiency Complicated With MELAS Syndrome Caused by UPB1 Variant and Mitochondrial Gene Variant Front. Pediatr., 21 February 2022 Sec. Genetics of Common and Rare Diseases Volume 10 - 2022 | https://doi.org/10.3389/fped.2022.838341
- Yilei Zheng, Tongling Liufu, BingWen, Chao Zhou, Lingchun Liu, YusenQiu, Wenquan Zou, Wei Zhang, Yu Li, Jianfeng Pei, Yiheng Zeng, Wanjin Chen, Chunhua Zhang , Yun Yuan, Guochun Wang, Chuanzhu Yan, Xin Lu, Jianwen Deng, Zhaoxia Wang and Daojun Hong COASY variant as a new genetic cause of riboflavin-responsive lipid storage myopathy Cell Discov. 2024 Feb 27;10(1):25. COASY variant as a new genetic cause of riboflavin-responsive lipid storage myopathy | Cell Discovery.